Overview
Not always — your Wegovy® starting dose when switching from Mounjaro® will depend on your current Mounjaro® dose and how long you've been using it. MedExpress aims to provide a personalised transition plan that maintains your weight-loss momentum while helping your body adapt comfortably.
Use this article when you want to:
Understand how MedExpress finds your closest-match Wegovy® starting dose
Find out when a lower "step down" Wegovy® dose is used for safety
Learn why a lower starting dose is a protective measure, not a loss of progress
How Is My Wegovy® Starting Dose Determined When Switching From Mounjaro®?
There is no exact one-to-one milligram match between Mounjaro® and Wegovy®, because they contain different active ingredients (tirzepatide and semaglutide respectively). However, MedExpress's clinicians follow established guidelines to find the safest Wegovy® starting dose for you:
If you're tolerating Mounjaro® well: if you've been on Mounjaro® without significant side effects, your MedExpress prescriber will typically start you on a Wegovy® dose that provides a similar level of appetite control.
If you've experienced side effects on Mounjaro®: if you've had persistent nausea, vomiting, or diarrhoea on Mounjaro®, MedExpress may recommend a "step down" to a lower Wegovy® starting dose. This allows your system to reset and adjust more gradually to Wegovy®.
Why Might I Start Wegovy® at a Lower Dose?
Starting at a slightly lower dose of Wegovy® is often a clinically safe way to maximise your comfort during the switch. It's important to remember:
It's not a step backwards: using a lower Wegovy® dose to manage side effects helps you stay on treatment longer, which is key to sustainable weight-loss results.
Clinical safety: reducing the risk of severe digestive upset during the first few weeks of your switch makes the transition to Wegovy® much smoother.
Titration: once your body has adjusted to Wegovy®, you can continue to move up the Wegovy® dose ladder as usual.