Both Wegovy® and Mounjaro® can cause digestive side effects as your body adjusts to the medication. While the types of symptoms are similar, clinical data suggests that the frequency of these side effects can vary depending on the treatment and the dose.
Use this guide to:
Compare the common side effects of both medications.
Understand the role of dose titration in symptom management.
See how most patients successfully manage these effects over time.
Common Side Effects
For both medications, the most frequently reported side effects are gastrointestinal, including:
Nausea
Diarrhoea
Vomiting
Constipation
Comparing the Data
Clinical studies suggest that digestive side effects occur slightly more often with Wegovy® than with Mounjaro®. When looking specifically at the incidence of nausea, data from clinical trials indicates:
Wegovy® (semaglutide): Approximately 44% of participants reported experiencing nausea.
Mounjaro® (tirzepatide): Approximately 12–22% of participants reported experiencing nausea.
Important Context on Dosage: It is important to note that clinical data shows a correlation between dosage and the incidence of these side effects. Higher maintenance doses are more likely to be associated with an increased frequency of nausea compared to starting or lower doses. This is a primary reason why both treatments use a gradual titration schedule—to help your body adjust safely and minimise the likelihood of these reactions.
Managing Your Treatment
While these percentages might seem high, it is important to look at the long-term experience of patients. Our data shows that 63% of people on Wegovy® who achieved meaningful weight loss after six months reported no side effects that affected their daily lives.
For most people, these symptoms are mild to moderate and typically ease as the body becomes accustomed to the medication and the titration schedule progresses.
Additional Resources
You can find more detailed information and practical tips for managing digestive discomfort in our Weight Loss Health Guide.
If you still need help after reviewing the information above, additional assistance is available from the MedExpress team.