Overview
Both Wegovy® and Mounjaro® can cause digestive side effects as your body adjusts to the medication. While the types of symptoms are similar, clinical data suggests the frequency of these side effects can vary depending on the treatment and the dose.
Use this article when you want to:
Compare the common side effects of Wegovy® and Mounjaro®.
Understand the role of dose titration in managing these symptoms.
See how most MedExpress patients successfully manage these effects over time.
What Are the Common Side Effects of Wegovy® and Mounjaro®?
For both medications, the most frequently reported side effects are gastrointestinal, including:
Nausea
Diarrhoea
Vomiting
Constipation
How Do Nausea Rates Compare Between Wegovy® and Mounjaro®?
Clinical studies suggest that digestive side effects occur slightly more often with Wegovy® than with Mounjaro®. When looking specifically at the incidence of nausea, data from clinical trials indicates:
Wegovy® (semaglutide): Approximately 44% of participants reported experiencing nausea.
Mounjaro® (tirzepatide): Approximately 12–22% of participants reported experiencing nausea.
It's important to note that clinical data shows a correlation between dosage and the incidence of these side effects — higher maintenance doses are more likely to be associated with an increased frequency of nausea, compared with starting or lower doses.
This is a primary reason why both Wegovy® and Mounjaro® use a gradual titration schedule, to help your body adjust safely and minimise the likelihood of these reactions.
How Do Most Patients Manage These Side Effects Over Time?
While these percentages might seem high, it's important to look at the long-term experience of patients. MedExpress data shows that 63% of people on Wegovy® who achieved meaningful weight loss after six months reported no side effects that affected their daily lives.
For most people, these symptoms are mild to moderate and typically ease as the body becomes accustomed to the medication and the titration schedule progresses.