Overview
MedExpress offers two prescription weight loss injectables, Mounjaro® and Wegovy®. Both support weight loss and appetite control, but they work differently and may suit different patients depending on your clinical needs and preferences.
Use this article when you want to:
Compare the key differences between Mounjaro® and Wegovy®
Understand how each medication works
See how Mounjaro®'s and Wegovy®'s effectiveness compares when used with consistent lifestyle support
Get guidance on choosing between Mounjaro® and Wegovy®, or on switching from one to the other
How Mounjaro® and Wegovy® Work
Mounjaro® (tirzepatide)
Mounjaro® targets two hormones, GIP and GLP-1, to reduce appetite and cravings, slow stomach emptying, and improve blood sugar control. When used alongside consistent lifestyle support, clinical trials indicate an average weight loss of approximately 20% of starting body weight on Mounjaro®.
Wegovy® (semaglutide)
Wegovy® targets one hormone, GLP-1, to increase feelings of fullness and reduce calorie intake. Clinical results for Wegovy® vary based on the maintenance dose used alongside consistent lifestyle support:
Wegovy® 2.4 mg: Average weight loss of approximately 15%
Wegovy® 7.2 mg: Average weight loss of approximately 20%
Key Differences at a Glance
Hormones targeted: Mounjaro® targets both GLP-1 and GIP (dual action); Wegovy® targets GLP-1 only.
Average weight loss: Mounjaro® achieves an average of approximately 20% of starting body weight; Wegovy® achieves approximately 15–20%, depending on the dose used.
Clinical profile: Mounjaro® is a highly effective dual-action treatment; Wegovy® is a highly effective GLP-1 agonist.
Mounjaro® and Wegovy® are considered on par with one another in terms of their ability to support significant, clinically meaningful weight loss.
Choosing or Switching Treatments
When to Stay on Your Current Treatment
You may prefer to stay on your current medication, whether that's Mounjaro® or Wegovy®, if you are seeing consistent progress, your side effects are manageable, and the treatment remains affordable. Staying on your current plan avoids the adjustment period associated with changing medications or dosing routines.
When to Consider Switching
You might consider switching between Mounjaro® and Wegovy® if you are looking for a more cost-effective option, prefer a different treatment profile, or wish to continue your progress with an alternative medication.
How the Right Treatment Is Chosen
A MedExpress prescriber will recommend the most suitable option, Mounjaro® or Wegovy®, based on:
Your BMI and medical history
Previous use of GLP-1 medications
Your tolerance to side effects
Your specific weight loss goals
Current safety and clinical guidelines
Switching Between Treatments
Switching between Mounjaro® and Wegovy® is a standard clinical process. If you decide to switch:
Your prescriber will recommend the appropriate starting dose for your new medication
You will receive clear guidance to ensure a safe and smooth transition between Mounjaro® and Wegovy®
Your treatment plan will be tailored to maintain your progress
Need Further Support?
If you still need help after reviewing the information above, additional assistance is available.