Certain medical conditions and risk factors mean weight loss injectable treatments such as Mounjaro® and Wegovy® must not be prescribed.
Overview
This article explains:
Medical situations where GLP-1 weight loss injections are contraindicated
Why these contraindications exist
How prescribers assess treatment safety
Use this information to understand when Mounjaro® or Wegovy® cannot be used.
Absolute contraindications
Weight loss injectables are not prescribed if a patient:
Is pregnant or breastfeeding
Personal or family history of medullary thyroid cancer
History of multiple endocrine neoplasia type 2 (MEN2)
Previous serious allergic reaction to the medication or its ingredients
Any condition where treatment would be clinically unsafe
These situations present unacceptable medical risk.
Other safety-related exclusions
Prescribers may also avoid treatment in cases of:
Severe gastrointestinal disease
Uncontrolled or unstable medical conditions
Use of conflicting or unsafe medications
Any factor preventing safe monitoring or adherence
Each case is assessed individually.
Why contraindications are strict
Contraindications are based on:
Clinical trial safety data
Regulatory prescribing guidance
Patient-safety standards
These safeguards ensure benefits outweigh risks before prescribing.
Key takeaway
Some medical conditions prevent safe use of Mounjaro® or Wegovy®.
Contraindications protect patient safety and treatment effectiveness.
A prescriber must confirm safety before medication is supplied.
If you still need help after reviewing the information above, additional assistance is available.